ARD-2585是一種口服有效的PROTAC雄激素受體降解劑，可用於治療晚期前列腺癌。肝微粒體穩定性測定、血漿穩定性測定和hERG測定通過hjc黄金城進行

A PROTAC-based androgen receptor (AR) degrader is a bifunctional small molecule, consisting of an AR ligand that binds to AR protein, and a ligand that binds to and recruits an E3 ligase complex, tethered together through a linker. Researchers report the discovery of exceptionally potent and orally bioavailable PROTAC AR degrader ARD-2585 (Compound 43). ARD-2585 is a promising AR degrader for extensive investigations for the treatment of advanced prostate cancer.

The liver microsomal stability assay was performed by Medicilon.

The plasma stability assay was performed by Medicilon.

The hERG assay was performed by Medicilon.

Reference:

Weiguo Xiang, et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64(18):13487-13509. doi: 10.1021/acs.jmedchem.1c00900.