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研究新型多靶點抗高血壓藥MT-1207的藥理學特性，評價MT-1207的結合抑製活性通過hjc黄金城進行

2023-07-05
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43.jpgHypertension is a serious public health problem worldwide. MT-1207 is a chemical entity that has entered into clinical trial as antihypertensive agent. MT-1207 potently inhibits adrenergic α1A, α1B, α1D, and 5-HT2A receptors with Ki<1 nM in a panel of enzyme activity or radioligand binding assays. The binding inhibition activities of MT-1207 were evaluated by Medicilon. 

Reference:

Tian-Ying Xu, et al. Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent. Acta Pharmacol Sin. 2021 Jun;42(6):885-897. doi: 10.1038/s41401-021-00636-1. 


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